Exploring the role of gut microbiota modulation in the long-term therapeutic benefits of early MSC transplantation in MRL/lpr mice
This research innovatively explores the early therapeutic window for MSCs in SLE, highlighting the partial mechanisms through which hUC-MSCs modulate the gut microbiota-tryptophan-AHR axis, thereby ameliorating SLE symptoms.
Authors
- Fengbiao Guo (ORCID: https://orcid.org/0000-0003-1953-5083)
- Lixin You (ORCID: https://orcid.org/0000-0002-0743-8676)
- Jiaxuan Chen (ORCID: https://orcid.org/0000-0001-5801-9052)
- Qingjun Pan (ORCID: https://orcid.org/0000-0002-8060-9099)
- Jialu Liu (ORCID: https://orcid.org/0000-0002-2956-7436)
- Zengzhi Xiao
- Quanren Pan (ORCID: https://orcid.org/0000-0002-4516-4557)
- Yanyan Huang (ORCID: https://orcid.org/0000-0002-2930-6471)
- Shuzhen Liao
- Xi Wang (ORCID: https://orcid.org/0000-0002-9698-300X)
- Xuemei Huang (ORCID: https://orcid.org/0000-0002-1883-9731)
- Lawei Yang (ORCID: https://orcid.org/0000-0002-8131-0443)
- Haiyan Xiao (ORCID: https://orcid.org/0000-0003-2878-337X)
- Haimin Huang
Institutions
- Guangdong Medical College (CN)
- Augusta University (US)
- Discovery Institute (US)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First People's Hospital of Foshan (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s11658-025-00716-8
- Citations
- 7
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 11.38
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province