CLINICO-EPIDEMIOLOGICAL SPECTRUM OF ACUTE KIDNEY INJURY (AKI) IN PATIENTS WITH CIRRHOSIS: INSIGHTS FROM A SINGLE CENTER IN NORTHEAST INDIA

Acute Kidney Injury (AKI) is a significant and often severe complication in patients with cirrhosis, leading to increased morbidity and mortality. In this retrospective study conducted at a tertiary care center in Northeast India, 143 cirrhotic patients were analyzed to assess the incidence, risk factors, and outcomes associated with AKI. The study found that 26.57% of patients developed AKI, with alcoholic liver disease (ALD) identified as the predominant underlying cause of cirrhosis in 89.47% of cases. Infections (39.47%) and Hepatorenal Syndrome (HRS)-AKI (31.58%) were the leading precipitating factors for AKI. Advanced age and a MELD score greater than 20 were significantly associated with the development of AKI. Patients who developed AKI had notably longer hospital stays, higher in-hospital mortality, and increased 28-day mortality compared to those without AKI. These findings underscore the critical need for early identification and targeted management of AKI in cirrhotic patients to improve clinical outcomes and reduce mortality