Design, Synthesis and Anti-Alzheimer's Activity of Some Hybrid Molecule of Oxymatrine Through TGF-β
This study unveils a new class of hybrid compounds derived from oxymatrine and amino acids that effectively target the TGF-β pathway, offering promising therapeutic potential for AD. These compounds demonstrate neuroprotective properties, suggesting they may mitigate ADrelated pathology, including tau deposition, synaptic dysfunction, and cognitive decline.
Authors
- Jaya Agnihotri (ORCID: https://orcid.org/0000-0001-7623-8507)
- Yogita Dhurandhar (ORCID: https://orcid.org/0009-0003-9825-1026)
- Subhendu Ghosh (ORCID: https://orcid.org/0000-0002-2070-8634)
- Ashmita Das (ORCID: https://orcid.org/0000-0001-8931-0598)
- Deepshikha Verma (ORCID: https://orcid.org/0000-0002-8549-6409)
- Manoj Kumar Sahoo (ORCID: https://orcid.org/0000-0002-9333-2690)
- Surendra H. Bodakhe (ORCID: https://orcid.org/0000-0002-9399-8337)
- Kamta Prashad Namdeo (ORCID: https://orcid.org/0000-0002-1319-0486)
- Durlav Chowdhury (ORCID: https://orcid.org/0009-0009-2329-691X)
Institutions
- Guru Ghasidas Vishwavidyalaya (IN)
Publication Details
- Journal
- Current Topics in Medicinal Chemistry
- Published
- 2025-04-17
- DOI
- https://doi.org/10.2174/0115680266345212250404071300
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00