Synthesis, Characterization, and Evaluation of Some Quinoline Derivatives as Possible Anti-Bacterial Agents

Four quinoline derivatives are synthesized by reflux reaction of isatin with beta keto ester. The studies of docking results show good hydrogen bonding using Molegro virtual docker software (MVD). Mentioned compounds exhibit Mol dock score between the range -78.3595 to -124.166 more as compare with standard ligand chloramphenicol i.e., -99.4262. Synthesized compounds were then characterized by 1H- NMR and FTIR and tested in-vitro. The synthesized compounds show good antibacterial activity against bacteria (E. coli, Staphylococcus aureus, S. typhi, B. subtilis).