Formulation and Evaluation of Orodispersible Tablet of Piroxicam by using Natrual Polymers

Piroxicam is an oxicam class of NSAID which is a drug of choice in the treatment of severe pains occurs in chronic diseases like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and many more severe conditions. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispercible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant. The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispercible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant. The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The formulation F2 found to be showing good results it was optimized. It has shown lesser time in disintegration i.e., 57 Sec.