Formulation and Characterization of Taste Mask Mouth Melt Film of Cetirizine HCl

The goal of the present study is to formulate and characterize taste mask mouth melt film containing cetirizine HCl to improve therapeutic efficacy by improving patient compliance and convenience for both younger and older patients. Varied batches of mouth melt films (MMF) of cetirizine HCl were prepared by the solvent casting process using varied quantities of HPMC K15, PVP K30, cross povidone, sodium starch glycolate, sucralose, orange flavour, aspartame citric acid used for increases salivation and colour also used. The films were assessed for physical appearance, weight variation, thickness, folding endurance, surface PH, drug content, disintegration time. The best formulation CTR6 exhibited acceptable folding endurance (150±1.03), least disintegration time (20±0.51 seconds), highest drug content (98.50±0.72mg) as compare to other formulation batches. The study concludes that formulation CTR6 of Mouth Melt Films for sublingual delivery of cetirizine HCl may be a best formulation than the other batches. The formulated batch can be a unique dosage form to better disintegration rate, beginning of action, and patient compliance. The best formulation (CTR6) yields satisfactory results.