Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches

MR analysis has demonstrated a significant positive causal relationship between PCOS and IBS, though the reverse causality from IBS to PCOS appeared non-significant. The genes CD14 and CASP1 emerged as potential shared diagnostic markers between these two conditions.

Authors

Yujun Zhang (ORCID: https://orcid.org/0000-0003-0150-6110)
Zhenglin Mei
Jingru Song (ORCID: https://orcid.org/0000-0002-1917-4890)
Wei Ye (ORCID: https://orcid.org/0000-0002-8211-1956)
Siyao Lv (ORCID: https://orcid.org/0009-0000-0453-7583)
Ziwei Gao (ORCID: https://orcid.org/0009-0007-2040-4669)

Institutions

Zhejiang Chinese Medical University (CN)
Tongde Hospital of Zhejiang Province (CN)
Hangzhou Hospital of Traditional Chinese Medicine (CN)

Publication Details

Journal: Endocrine Metabolic & Immune Disorders - Drug Targets
Published: 2025-04-16
DOI: https://doi.org/10.2174/0118715303363459250317084005
Primary Topic: Eosinophilic Esophagitis
Type: article
Field-Weighted Citation Impact: 0.00

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article

Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches

Yujun Zhang, Zhenglin Mei, Jingru Song, Wei Ye et al.

Apr 16, 2025

Endocrine Metabolic & Immune Disorders - Drug Targets

Eosinophilic Esophagitis

article

Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches

Yujun Zhang, Zhenglin Mei, Jingru Song, Wei Ye, Siyao Lv, Ziwei Gao

April 16, 2025article en

Abstract

MR analysis has demonstrated a significant positive causal relationship between PCOS and IBS, though the reverse causality from IBS to PCOS appeared non-significant. The genes CD14 and CASP1 emerged as potential shared diagnostic markers between these two conditions.

Endocrine Metabolic & Immune Disorders - Drug TargetsVol. 25

Zhejiang Chinese Medical University (CN), Tongde Hospital of Zhejiang Province (CN), Hangzhou Hospital of Traditional Chinese Medicine (CN)

Openalex Percentile: Top 86%

Eosinophilic Esophagitis

DOI Source OpenAlex

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Exploring the Genetic Link between Irritable Bowel Syndrome and Polycystic Ovary Syndrome: Bidirectional Mendelian Randomization and Machine Learning Approaches — Yujun Zhang, Zhenglin Mei, et al. · Endocrine Metabolic & Immune Disorders - Drug Targets (2025) | TGRS Research Map | TGRS