A Comprehensive 4-layered In Silico Pharmacogenomics Analysis of the Genetic Addiction Risk Severity (GARS) Test: Strong Genetic Evidence Supporting GARS as a Novel Personalized Pre-addiction Assessment Tool in the Opioid Crisis Era
This paper provides scientific evidence for the importance of incorporating GARS as a predictive test to identify Pre-addiction, introduce unique therapeutic targets assisting in the treatment of pain, drug dosing of prescription pharmaceuticals, and identify the risk for subsequent addiction early in -life.
Authors
- Panayotis K. Thanos (ORCID: https://orcid.org/0000-0002-5663-3478)
- Rossano Kepler Alvim Fiorelli (ORCID: https://orcid.org/0000-0001-5236-0903)
- Foojan Zeine (ORCID: https://orcid.org/0009-0006-7709-5580)
- Edward J. Modestino (ORCID: https://orcid.org/0000-0001-7611-5144)
- Eliot L. Gardner (ORCID: https://orcid.org/0000-0003-1541-3249)
- Colin Hanna
- David Baron (ORCID: https://orcid.org/0000-0001-7670-2613)
- Jag Khalsa (ORCID: https://orcid.org/0000-0002-6534-3616)
- Jean Lud Cadet (ORCID: https://orcid.org/0000-0001-5635-3524)
- Marjorie C. Gondré‐Lewis
- Daniel Sipple
- Nicole Jafari (ORCID: https://orcid.org/0000-0001-7762-9673)
- Abdalla Bowirrat (ORCID: https://orcid.org/0000-0001-8185-0688)
- Igor Elman (ORCID: https://orcid.org/0000-0002-1345-2677)
- Albert Pinhasov (ORCID: https://orcid.org/0000-0001-8116-4565)
- Keerthy Sunder
- Milan Makale (ORCID: https://orcid.org/0000-0001-5414-0517)
- Catherine A. Dennen
- Mark S. Gold
- Kai-Uwe Lewandrowski
- Kevin T. Murphy
- Eric R. Braverman (ORCID: https://orcid.org/0000-0001-5525-8314)
- Kenneth Blum
- Rajendra D. Badgaiyan (ORCID: https://orcid.org/0000-0001-5586-5114)
- EraAlireza Sharafshah
Institutions
- University of California, Riverside (US)
- Cambridge Health Alliance (US)
- National Institutes of Health (US)
- National Institute on Drug Abuse (US)
- Harvard University (US)
- Guilan University of Medical Sciences (IR)
- Washington University in St. Louis (US)
- Thomas Jefferson University Hospital (US)
- UC San Diego Health System (US)
- University of California San Diego (US)
- Hospital Universitário Gaffrée e Guinle (BR)
- Minneapolis Business College (US)
- Northeast Health (US)
- University School (US)
- Michigan Head and Spine Institute (US)
- Fundación Universitaria Sanitas (CO)
- Curry College (US)
- Ariel University (IL)
- Case Western Reserve University (US)
- California State University, Long Beach (US)
- Universidade Federal do Estado do Rio de Janeiro (BR)
- The Chicago School (US)
- Western University of Health Sciences (US)
Publication Details
- Journal
- Current Pharmaceutical Biotechnology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.2174/0113892010353450250408114725
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00