Hypoxic Preconditioning Enhances the Potential of Mesenchymal Stem Cells to Treat Neonatal Hypoxic-Ischemic Brain Injury
This study shows for the first time that hypoxic preconditioning enhanced the therapeutic efficacy of MSC therapy in a mouse model of neonatal HI brain injury by increasing the migratory and neuroregenerative capacity of MSCs.
Authors
- Sabine van Rijt (ORCID: https://orcid.org/0000-0003-4102-4626)
- Tatiana M. Shamorkina (ORCID: https://orcid.org/0000-0002-4191-6061)
- Eva C. Hermans
- Albert J. R. Heck (ORCID: https://orcid.org/0000-0002-2405-4404)
- Caroline G. M. de Theije (ORCID: https://orcid.org/0000-0003-1265-7897)
- Cora H. Nijboer (ORCID: https://orcid.org/0000-0003-1223-1861)
- Stephanie Palma (ORCID: https://orcid.org/0009-0001-5943-8539)
- Chloe Trayford (ORCID: https://orcid.org/0009-0003-4514-1704)
Institutions
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Netherlands Metabolomics Centre (NL)
- Regenerative Medicine Institute (MX)
- Wilhelmina Children's Hospital (NL)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1161/strokeaha.124.048964
- Citations
- 8
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 13.00