IGF-1 Provides Protective Role in Arteriosclerotic Cerebral Small Vessel Disease
Low serum IGF-1 was associated with greater arteriosclerotic cSVD severity. IGF-1 treatment improved cerebral perfusion, blood-brain barrier integrity, and cognitive function in cSVD rats by activating the IGF-1R/Wnt7b/β-catenin pathway, suggesting a potential therapeutic strategy for patients with arteriosclerotic cSVD, particularly those with low IGF-1 levels.
Authors
- Liuting Hu (ORCID: https://orcid.org/0000-0003-3415-4975)
- Wenli Zhou (ORCID: https://orcid.org/0000-0002-6975-2206)
- Jing Yang (ORCID: https://orcid.org/0000-0003-2733-8629)
- Kun Zhou (ORCID: https://orcid.org/0000-0003-2955-9804)
- Yuhua Fan (ORCID: https://orcid.org/0000-0002-1172-1490)
- Linfang Lan (ORCID: https://orcid.org/0000-0003-0044-8350)
- Jiayu Guo (ORCID: https://orcid.org/0009-0008-7015-6437)
- Xiangming Xu (ORCID: https://orcid.org/0000-0002-0313-718X)
- Chi Xiao (ORCID: https://orcid.org/0000-0002-1522-1928)
- Ming Yi (ORCID: https://orcid.org/0000-0003-1743-9899)
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1161/hypertensionaha.124.24341
- Citations
- 3
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.17