Podocyte Injury and Traditional Chinese Medicine Diagnosis and Treatment of Membranous Nephropathy

特发性膜性肾病(Idiopathic Membranous Nephropathy, IMN)是一种发病原因不明的自身免疫疾病，其主要为循环抗体和靶抗原在肾小球基底膜外侧结合，引起上皮下免疫复合物沉积、基底膜增厚的病症，通常可见严重的蛋白尿。近年来，各专家研究足细胞损伤和中医药治疗取得了一定的进展，中医药诊疗膜性肾病存在优势，临床上采用单味中药、中药制剂、方剂等疗法，在缓解膜性肾病难治症状、改善预后、预防复发等方面有一定效果，应用前景良好。结合近年来的相关文献，论述膜性肾病发病机制，旨在进一步为中医药治疗特发性膜性肾病的研究提供新的思路。Idiopathic Membranous Nephropathy (IMN) is an autoimmune disease of unknown pathogenesis, which is primarily a condition in which circulating antibodies and target antigens bind to the outer glomerular basement membrane, causing thickening of the basement membrane due to the deposition of immune complexes, which often manifests as severe proteinuria. It often manifests as severe proteinuria. In recent years, experts have made some progress in studying podocyte damage and traditional Chinese medicine treatment. Traditional Chinese medicine has advantages in the diagnosis and treatment of membranous nephropathy. In clinical practice, single Chinese medicine, Chinese medicine preparations, prescriptions, and other therapies have been used to alleviate refractory symptoms of membranous nephropathy, improve prognosis, and prevent recurrence, with certain effects and good application prospects. Based on relevant literature in recent years, this article discusses the pathogenesis of membranous nephropathy, aiming to provide new ideas for the treatment of idiopathic membranous nephropathy with traditional Chinese medicine.