Neurogenic disorders of salivation and sleep in conditions of martial law and military aggression against the background of chronic stress and anxiety. Combined therapy

Background. The article focuses on the study of neurogenic disorders of salivation and sleep caused by chronic stress in the difficult conditions of martial law and military aggression. According to current research, the prevalence of these disorders reaches 42–57% among civilians; 65–78% among military personnel; 82% among internally displaced persons. Prolonged activation of the stress system leads to an increase in cortisol levels by 2.5–3 times, which directly affects the functioning of the salivary glands due to impaired adrenergic regulation. Purpose – to increase the effectiveness of treatment of neurogenic disorders of salivation and sleep through the integrated use of sensory deprivation and psychotherapy against the background of drug infusion anti-inflammatory therapy. Materials and Methods. The article analyzes in detail the composition and functional features of saliva, including its buffering capacity and the content of enzymes that play a key role in protecting the oral cavity and overall health. Study design. A prospective randomized controlled trial lasting 8 weeks with a 12-week follow-up period. Study participants – 60 patients (25–45 years old) – were divided into groups: 1. Control (n = 20): healthy volunteers; 2. Standard therapy (n = 20); 3. Comprehensive treatment (n = 20). Assessment methods: 1. Sialometry (basal and stimulated); 2. Biochemical markers (cortisol, catecholamines); 3. Psychometric testing; 4. Assessment of sleep quality. Results. The role of saliva components in physiological processes and the impact of stress on neurogenic salivation and sleep is very important. The biochemical composition of saliva is a complex biofluid that plays a critical role in maintaining oral health and overall homeostasis of the oral cavity and the human body. Indicators of salivary secretion: Basal secretion (ml/min): – Control: 0.45 ± 0.05; – Group 2 after treatment: 0.31 ± 0.04; – Group 3 after treatment: 0.42 ± 0.04 (p < 0.001). Biochemical markers: Cortisol levels (nmol/L): – Control: 14.2 ± 2.1; – Group 2 after treatment: 25.4 ± 3.2; – Group 3 after treatment: 16.8 ± 2.4 (p < 0.001). Psychometric indicators: Anxiety reduction: – Group 2: 42%; – Group 3: 68% (p < 0.001). Conclusions. The role of salivary components in physiological processes and the impact of stress on neurogenic salivation and sleep is very important. The biochemical composition of saliva is a complex biological fluid that plays an important role in maintaining oral health and the overall homeostasis of the oral cavity and the human body. The study confirmed a significant improvement in the condition of patients in the third group, indicating the potential of these methods in the treatment of disorders associated with chronic stress. Comprehensive treatment demonstrates higher efficiency compared to standard therapy. Normalization of the psychoemotional state correlates with the restoration of physiological functions. Sustained remission was achieved in 85% of patients in the complex treatment group. Practical recommendations: 1. The treatment duration is 8 weeks. 2. Sensory deprivation – 3 times/week. 3. Psychotherapy – 2 sessions/week. 4. Biomarker monitoring every 2 weeks.