Successful Management of Repeated Oligometastatic Squamous Cell Carcinoma of the Mouth Floor with Metastasectomy and Maintenance Tegafur-plus-uracil: A Case Report

Abstract This case report describes a patient with poorly differentiated squamous cell carcinoma (PD SqCC) of the mouth floor, staged as pT4aN0M0. The initial treatment comprised surgical resection followed by adjuvant concurrent chemoradiotherapy. The patient subsequently experienced metastatic recurrence of poorly differentiated carcinoma, first in the lung and later in the pancreas. Two rounds of metastasectomy were performed. Despite the complexity of multiagent systemic therapies, the patient was maintained on tegafur-plus-uracil therapy following the two metastasectomies, leading to long-term disease-free survival. This case illustrates that with careful recognition of oligorelapse and oligoprogression, metastatic head-and-neck cancer can be effectively managed with a more simplified therapeutic approach.