Enhancement of the endocannabinoid system through monoacylglycerol lipase inhibition relieves migraine-associated pain in mice
MAGL inhibitor effectively blocked acute and chronic migraine-associated pain, likely through prolonged endocannabinoid action. This effect may be mediated through action at peripheral or central sites considering the high MAGL and CB<sub>1</sub> expression in the TG and TNC, respectively. The endocannabinoid system appears to modulate migraine mechanisms, and MAGL may be a promising target for this disorder.
Authors
- Yaseen Awad-Igbaria (ORCID: https://orcid.org/0000-0002-8418-8404)
- Elizaveta Mangutov
- Kendra Siegersma (ORCID: https://orcid.org/0000-0002-6578-5561)
- François Gastambide
- Amynah Pradhan (ORCID: https://orcid.org/0000-0001-9691-2976)
- Ayodeji A. Asuni (ORCID: https://orcid.org/0000-0003-3488-6893)
Institutions
- Lundbeck (Denmark) (DK)
- Washington University in St. Louis (US)
- University of Illinois Chicago (US)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s10194-025-02029-9
- Citations
- 3
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- H. Lundbeck A/S