SPECTRUM OF HISTOPATHOLOGICAL STUDY IN URINARY BLADDER BIOPSIES – A PROSPECTIVE STUDY

Background: The urinary bladder is commonly affected by both non-neoplastic and neoplastic lesions, with bladder tumors ranking as the 10th most common malignancy worldwide. Hematuria and increased urinary frequency are frequent presenting symptoms. Aim: Materials And Methods: To study the frequency and histopathological spectrum of bladder lesions. A prospective study was conducted from November 2022 to October 2023 at KLE's Dr. Prabhakar Kore Hospital, Belagavi. A total of 45 bladder biopsies (22 TURBT and 23 cystoscopic) were analyzed. Results: Out of the 45 cases, 15 (33.3%) were non-neoplastic and 30 (66.7%) were neoplastic. Most patients were males (71.1%) aged 30–70 years. Chronic cystitis was the most common non-neoplastic lesion. Invasive papillary urothelial carcinoma was the most frequent tumor (40%). High-grade variants were more common (53.3%), with 75% showing muscle invasion. Conclusion: Neoplastic lesions, especially high-grade invasive papillary urothelial carcinomas, are the most frequent. Grading, staging, and muscle invasion are crucial prognostic indicators.