Repeated treatment with JWH-018 progressively increases motor activity and aggressiveness in male mice: involvement of CB1 cannabinoid and D1/D2 dopaminergic receptors
The present results demonstrated that repeated treatment with high dosage of JWH-018 induces psycho-stimulants effects via both CB<sub>1</sub> receptor-mediated and dopamine-dependent mechanisms.
Authors
- Sabrine Bilel (ORCID: https://orcid.org/0000-0003-1515-980X)
- Giorgia Corli (ORCID: https://orcid.org/0000-0002-2973-2446)
- Paola Rossi (ORCID: https://orcid.org/0000-0002-1134-4111)
- Matteo Marti (ORCID: https://orcid.org/0000-0001-8751-2882)
- Fabrizio De Luca (ORCID: https://orcid.org/0000-0002-6462-2373)
- Marta Bassi (ORCID: https://orcid.org/0009-0008-3753-4627)
- C. Locatelli (ORCID: https://orcid.org/0000-0003-2154-5897)
- E. Roda (ORCID: https://orcid.org/0000-0001-7590-5363)
- Liana Fattore (ORCID: https://orcid.org/0000-0002-2663-666X)
Institutions
- University of Cagliari (IT)
- University of Ferrara (IT)
- University of Pavia (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- Union des Industries Ferroviaires Européennes (BE)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177633
- Citations
- 1
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39