ULK2 deficiency stratifies autophagy-driven molecular subtypes and exacerbates trophoblasts apoptosis in preeclampsia
ULK2 deficiency disrupts trophoblast homeostasis, driving placental dysfunction and severe clinical outcomes. The ULK2<sup>low</sup> subtype highlights autophagy heterogeneity in PE. While pharmacological ULK2 inhibition recapitulates PE in mice, limitations include sample size and MRT68921's dual ULK1/2 activity. Our findings propose ULK2 agonism as novel therapeutic strategies.
Authors
- Yutong Cui (ORCID: https://orcid.org/0000-0002-5929-5101)
- J SHAO (ORCID: https://orcid.org/0000-0001-5899-1490)
- Huangfang Xu (ORCID: https://orcid.org/0000-0002-2929-8790)
- Qiongjie Zhou (ORCID: https://orcid.org/0000-0002-1264-161X)
- Wenhan Zhou (ORCID: https://orcid.org/0000-0001-8160-6394)
- Huanqiang Zhao (ORCID: https://orcid.org/0000-0002-3664-8031)
- Suwen Wu (ORCID: https://orcid.org/0000-0002-2772-6480)
- Jianfeng Gan
- Yinan Wang (ORCID: https://orcid.org/0000-0001-8714-2105)
- Xiaotian Li (ORCID: https://orcid.org/0000-0002-2051-4581)
Institutions
- Shenzhen Maternity and Child Healthcare Hospital (CN)
- Wuhan Union Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Placenta
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1016/j.placenta.2025.04.015
- Primary Topic
- Pregnancy and preeclampsia studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00