Detection of SARS-CoV-2 in Ascitic Fluid of Cirrhotic COVID-19 Patients: Case Series and Literature Review

SARS-CoV-2 has been identified in multiple organs and fluids, including the liver and peritoneal fluid. Gastrointestinal symptoms, such as abdominal pain, diarrhea, nausea, and vomiting, can exacerbate COVID-19 outcomes by contributing to complications, like acid–base imbalances and cardiovascular dysfunction, particularly in patients with pre-existing conditions. We report three cases of COVID-19 cirrhotic patients with SARS-CoV-2 detected in their ascitic fluid and review the relevant literature on the virus’s presence and clinical significance in peritoneal fluid. These findings underscore diagnostic and prognostic challenges in managing COVID-19 in patients with chronic liver disease and highlight the need for further research to clarify viral dissemination mechanisms and optimize protective measures for healthcare workers during surgical procedures.

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Publication Details

Journal
COVID
Published
2025-04-18
DOI
https://doi.org/10.3390/covid5040058
Primary Topic
COVID-19 Clinical Research Studies
Type
article
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article

Detection of SARS-CoV-2 in Ascitic Fluid of Cirrhotic COVID-19 Patients: Case Series and Literature Review

Ylenia Russotto, Giuseppe Mancuso, Cristina Micali, Emmanuele Venanzi Rullo et al.
COVID
COVID-19 Clinical Research Studies
article

Detection of SARS-CoV-2 in Ascitic Fluid of Cirrhotic COVID-19 Patients: Case Series and Literature Review

Ylenia Russotto, Giuseppe Mancuso, Cristina Micali, Emmanuele Venanzi Rullo, Grazia Caci, Edoardo Campanella, Aldo Sitibondo, Roberto Filomia, Giuseppe Nunnari, Natascia Laganà, Angelina Midiri, Andrea Marıno, Giovanni Francesco Pellicanò, Serena Spampinato, Antonino Botindari
article en

Abstract

SARS-CoV-2 has been identified in multiple organs and fluids, including the liver and peritoneal fluid. Gastrointestinal symptoms, such as abdominal pain, diarrhea, nausea, and vomiting, can exacerbate COVID-19 outcomes by contributing to complications, like acid–base imbalances and cardiovascular dysfunction, particularly in patients with pre-existing conditions. We report three cases of COVID-19 cirrhotic patients with SARS-CoV-2 detected in their ascitic fluid and review the relevant literature on the virus’s presence and clinical significance in peritoneal fluid. These findings underscore diagnostic and prognostic challenges in managing COVID-19 in patients with chronic liver disease and highlight the need for further research to clarify viral dissemination mechanisms and optimize protective measures for healthcare workers during surgical procedures.

COVIDVol. 5(4)
University of Messina (IT), University of Catania (IT), Policlinico Universitario di Catania (IT)
Openalex Percentile: Top 89%
COVID-19 Clinical Research Studies
DOIOpen Access PDFOpenAlex
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Detection of SARS-CoV-2 in Ascitic Fluid of Cirrhotic COVID-19 Patients: Case Series and Literature Review — Ylenia Russotto, Giuseppe Mancuso, et al. · COVID (2025) | TGRS Research Map | TGRS