Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization
Our study provides robust genetic evidence supporting that the genetic predisposition to GERD is associated with an increased risk of PC. These findings emphasize the necessity of integrating GERD into PC risk assessments and encourage further research to elucidate the underlying biological mechanisms. This insight holds potential to inform strategies for early detection, prevention, and personalized management of PC in GERD patients.
Authors
- Fan Ge (ORCID: https://orcid.org/0000-0002-6599-8807)
- Chen Yang (ORCID: https://orcid.org/0000-0002-9797-982X)
- Kezheng Wang (ORCID: https://orcid.org/0000-0001-8776-5812)
- Mengye Peng
- Wei Liu (ORCID: https://orcid.org/0000-0002-9302-8170)
- Liang Cheng (ORCID: https://orcid.org/0009-0004-2260-6254)
Institutions
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12885-025-14128-6
- Citations
- 2
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.62
Funders
- Harbin Medical University
- Key Research and Development Program of Heilongjiang
- National Natural Science Foundation of China