Novel PD-1-targeted, activity-optimized IL-15 mutein SOT201 acting in cis provides antitumor activity superior to PD1-IL2v
SOT201 represents a promising therapeutic candidate that preferentially targets PD-1<sup>+</sup> TILs, delivering balanced cytokine activity for reviving CD8<sup>+</sup> Tex cells in tumors. SOT201 is currently being evaluated in the Phase I clinical study VICTORIA-01 (NCT06163391) in patients with advanced metastatic cancer.
Authors
- Romana Mikyšková (ORCID: https://orcid.org/0000-0002-6857-1155)
- Radek Špíšek
- Kamila Hladíková
- Klára Dáňová
- Hana Matušková
- Milada Šírová (ORCID: https://orcid.org/0000-0002-7645-1495)
- Matej Fabišik (ORCID: https://orcid.org/0000-0003-2347-245X)
- David Béchard (ORCID: https://orcid.org/0000-0003-1817-3324)
- Lucie Košinová (ORCID: https://orcid.org/0000-0001-5837-5508)
- Nada Podzimkova
- Petr Daněk (ORCID: https://orcid.org/0000-0002-6552-2219)
- Milan Reiniš (ORCID: https://orcid.org/0000-0001-7083-2898)
- Dario Greco (ORCID: https://orcid.org/0000-0001-9195-9003)
- Vladyslav Mazhara
- Martin Steegmaier
- Irena Adkins
- Pavel Marášek
- Zuzana Antosova
- Ulrich Moebius
- Marek Kovář (ORCID: https://orcid.org/0000-0002-6602-1678)
- Katerina Sajnerova
- Iva Malatova
- Kateřina Běhalová
- Lenka Palová Jelínková
- Ekaterina Simonova (ORCID: https://orcid.org/0009-0005-6068-2335)
- Klara Hrabankova
- Ondrej Martinec
Institutions
- Czech Academy of Sciences (CZ)
- Charles University (CZ)
- Institute of Microbiology (BY)
- ATLAB Pharma (France) (FR)
- Sotio (Czechia) (CZ)
- Institute of Molecular Genetics (RU)
- Czech Academy of Sciences, Institute of Molecular Genetics (CZ)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1136/jitc-2024-010736
- Citations
- 5
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 3.99
Funders
- Ústav Molekulární Genetiky, Akademie Věd České Republiky
- Mikrobiologický Ústav, Akademie Věd České Republiky