EVALUATION OF ANTIEPILEPTIC ACTIVITY OF CASSIA AURICULATA FLOWER EXTRACTS IN MICE

Objective: To evaluate the antiepileptic activity and estimate brain biogenic amines in mice treated with ethanolic extracts of Cassia auriculata flowers (EECA). Methods: Anticonvulsant activities of EECA were assessed using Maximal Electroshock Seizure (MES), Pentylenetetrazole (PTZ), and Strychnine-induced seizure models in mice. Biogenic amine levels were estimated via HPLC. Results: EECA significantly reduced tonic hind limb extension in the MES model and delayed seizure onset in PTZ and Strychnine models. Brain dopamine and noradrenaline levels increased post-EECA treatment. Motor coordination tests indicated mild impairment at anticonvulsant doses.Conclusion: EECA demonstrates dose-dependent antiepileptic activity, likely due to flavonoids and antioxidant phytoconstituents.