Adjuvant dendritic cell-based immunotherapy in melanoma: insights into immune cell dynamics and clinical evidence from a phase II trial
Our findings support the safety and tolerability of DC vaccination as an adjuvant treatment for melanoma, demonstrating significant immune modulation at both the tumor site and peripherally in relapsed and non-relapsed patients. These results highlight the potential of autologous, personalised DC-based therapies and pave the way for the development of innovative immunotherapy combinations in future treatment strategies. Trial registration ClinicalTrials.gov NCT02718391; EudraCT no. 2014-005123-27.
Authors
- Valentina Ancarani (ORCID: https://orcid.org/0000-0001-7571-8605)
- Emanuela Scarpi (ORCID: https://orcid.org/0000-0001-7230-9267)
- Francesco Limarzi (ORCID: https://orcid.org/0000-0002-1367-3525)
- Jenny Bulgarelli (ORCID: https://orcid.org/0000-0002-6551-0189)
- Massimo Guidoboni (ORCID: https://orcid.org/0000-0001-7703-790X)
- Francesca Tauceri
- Francesco De Rosa (ORCID: https://orcid.org/0000-0003-0511-1298)
- Silvia Carloni (ORCID: https://orcid.org/0000-0003-1646-7134)
- Elena Pancisi (ORCID: https://orcid.org/0000-0002-8780-2342)
- Livia Turci (ORCID: https://orcid.org/0000-0003-3035-7767)
- L. Renzi (ORCID: https://orcid.org/0000-0002-0250-9033)
- Laura Capelli (ORCID: https://orcid.org/0000-0002-6624-7730)
- Giovanni Foschi (ORCID: https://orcid.org/0000-0003-2164-3032)
- Marcella Tazzari (ORCID: https://orcid.org/0000-0002-8112-1773)
- Laura Ridolfi (ORCID: https://orcid.org/0000-0003-1870-3380)
- Pietro Cortesi
- S Baravelli
- Claudia Piccinini (ORCID: https://orcid.org/0000-0001-5862-6207)
- Massimiliano Petrini (ORCID: https://orcid.org/0000-0002-8942-0890)
- Maria Maddalena Tumedei (ORCID: https://orcid.org/0000-0003-3105-9796)
- Sara Pignatta (ORCID: https://orcid.org/0000-0001-5464-0052)
- Ilaria Bronico
- Anna Maria Granato (ORCID: https://orcid.org/0000-0002-8609-4217)
- Massimo Framarini
- Diana Fanelli (ORCID: https://orcid.org/0000-0003-0863-5898)
- G. Gentili
Institutions
- University of Ferrara (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Ospedale G.B. Morgagni - L.Pierantoni (IT)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-18
- DOI
- https://doi.org/10.1186/s12967-025-06403-8
- Citations
- 3
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Ministero della Salute