Extreme temperatures modulate gene expression in the airway epithelium of the lungs in mice and asthma patients
Our study highlights the effects of extreme temperatures on the gene signature of the airway epithelium in both mice and asthma patients. These findings suggest that extreme temperatures modulate gene expression in the airway epithelium, potentially serving as clinical indicators or biomarkers in response to climate change.
Authors
- Kai-Jen Chuang (ORCID: https://orcid.org/0000-0003-4884-6446)
- Desy Rusmawatiningtyas (ORCID: https://orcid.org/0000-0003-1676-8383)
- Feng‐Ming Yang (ORCID: https://orcid.org/0000-0003-4857-4516)
- Yuan‐Hung Wang (ORCID: https://orcid.org/0000-0001-5570-2622)
- Hsiao‐Chi Chuang (ORCID: https://orcid.org/0000-0003-4651-5192)
- Indah Kartika Murni (ORCID: https://orcid.org/0000-0003-1275-9180)
- Kang-Yun Lee (ORCID: https://orcid.org/0000-0002-1203-4094)
- Kian Fan Chung (ORCID: https://orcid.org/0000-0001-7101-1426)
- Ta-Chih Hsiao (ORCID: https://orcid.org/0000-0003-4103-6272)
- Shu‐Chuan Ho (ORCID: https://orcid.org/0000-0002-1616-8647)
- Syue-Wei Peng
- Eggi Arguni (ORCID: https://orcid.org/0000-0001-7462-7904)
- Firdian Makrufardi (ORCID: https://orcid.org/0000-0001-5376-5478)
- Kin‐Fai Ho (ORCID: https://orcid.org/0000-0001-7464-3437)
- Marc Chadeau‐Hyam (ORCID: https://orcid.org/0000-0001-8341-5436)
- Sheng-Chieh Lin
Institutions
- National Taiwan University (TW)
- Chinese University of Hong Kong (HK)
- Wan Fang Hospital (TW)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Imperial College London (GB)
- Taipei Medical University (TW)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fmed.2025.1531154
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- Ministry of Education, India
- National Science and Technology Council