Heart Failure With Preserved Ejection Fraction Phenotype Is Associated With Early Symptom Onset in Aortic Stenosis and Residual Symptoms After Transcatheter Aortic Valve Implantation
Patients with aortic stenosis with a heart failure with preserved ejection fraction phenotype are more likely to develop symptoms at lower gradients and have worse outcomes post-TAVI. Randomized trials are warranted to investigate whether medical therapy targeted at heart failure with preserved ejection fraction delays onset of symptoms and improves symptomatic response after TAVI.
Authors
- Nicolas Girerd (ORCID: https://orcid.org/0000-0002-3278-2057)
- Joanna J. Wykrzykowska (ORCID: https://orcid.org/0000-0001-7577-4084)
- Kees H. van Bergeijk (ORCID: https://orcid.org/0000-0001-6271-0567)
- Yvonne L. Douglas (ORCID: https://orcid.org/0000-0003-2274-8995)
- Ify Mordi (ORCID: https://orcid.org/0000-0002-2686-729X)
- Hindrik W. van der Werf (ORCID: https://orcid.org/0009-0003-5441-2668)
- Michiel Rienstra (ORCID: https://orcid.org/0000-0002-2581-070X)
- Carolyn S.P. Lam (ORCID: https://orcid.org/0000-0003-1903-0018)
- Chim C. Lang (ORCID: https://orcid.org/0000-0002-4530-3078)
- Constantijn S. Venema (ORCID: https://orcid.org/0000-0002-6273-9287)
- Adriaan A. Voors (ORCID: https://orcid.org/0000-0002-5417-4415)
- Erik Lipšic (ORCID: https://orcid.org/0000-0002-7407-3064)
- Martin B Leon
- Ad F.M. van den Heuvel (ORCID: https://orcid.org/0000-0002-0385-0524)
- Jan A. Krikken
Institutions
- University Medical Center Groningen (NL)
- NewYork–Presbyterian Hospital (US)
- National University of Singapore (SG)
- University of Groningen (NL)
- University of Dundee (GB)
- Columbia University Irving Medical Center (US)
- New York Hospital Queens (US)
- National University Heart Centre Singapore (SG)
- Cardiovascular Research Foundation (US)
- Centre d'Investigation Clinique Pierre Drouin (FR)
- National Heart Centre Singapore (SG)
- Défaillance Cardiovasculaire Aiguë et Chronique
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1161/jaha.124.038786
- Citations
- 2
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.78