Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Tenecteplase was not associated with better clinical outcomes over nonthrombolytic control in female or male patients with minor ischemic stroke, despite more frequent recanalization. Fewer women treated with tenecteplase returned to baseline function compared with men.

Authors

Institutions

Publication Details

Journal
Journal of the American Heart Association
Published
2025-04-17
DOI
https://doi.org/10.1161/jaha.124.039154
Citations
1
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
1.35
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Michael D. Evans, Érin Collins, Robert Cody, Wyllians Vendramini Borelli et al.
1 citations
Journal of the American Heart Association
Acute Ischemic Stroke Management
1.35
article

Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Michael D. Evans, Érin Collins, Robert Cody, Wyllians Vendramini Borelli, Michael Valente, D Kalladka, Luciane Cristina Vieira, C. Vandervelde, Sebastián Fridman, Carlos García Esperón, Mohammed A. Alskaini, Arshad Muhammad Iqbal, Alicia D’Souza, J Khaira, Andrew Chew, Edoardo Bardi, Michael Haji-Coll, Sarah Coveney, Patrick Tan, Steven A. Frost, Tanya Frost, Julia Ferrari, C Rapier, A. Menon, Princess King-Azote, Matheus Bernardon Morillos, Jack Homer, J Good, R. Starling de Barros, Darshan Ghia, Samuel J. Mann, Ivan Wiggam, Houman Khosravani, Kaitlynn M. Lopes, Lissa Peeling, Najla Popel, Pawel Kostyrko, Maria Österdahl, Elisabeth Rounis, David M. Kent, P Mathieson, Fabrício Oliveira Lima, Kathryn S. Lilley, Bryce A. Durafourt, Jhoanna N. Aquino, Julie Kromm, Jacquelyn Harvey, Carmen Martín, Sara Khalil, Stephen G. Waller, Piyush Ojha, Emily Junk, Hang Zhao, Ivie Gbinigie, Cheryl Jaigobin, Vignan Yogendrakumar, Paige Fairall, Riccardo Cerantola, Marián Muchada, Aleksandra Pikula, Salwa Elmamoun, Mowad Benguzzi, Kim Hatherley, E MacRae, Matthew Large, Jacob George, S Mashate, Annette Haché, Luciano Alberto Sposato, M Willmot, Shelagh B. Coutts, Kanchana Ratnayake, Joanna D. Schaafsma, Robert Irons, Haylee Berrill, Montse Olivé, Darshan Shah, Liisa Tomppo, Matías Deck, Angelos Sharobeam, Anne Cayley, Tianming Teng, Thomas G. Stewart, Elizabeth Hayter, Tamara Canento Sánchez, Rajesh Kumar Singh, Susan B. Roberts, Manuel Requena, Rachel Goh, Eric Edward Smith, Colleen Murphy, Marina Salluzzi, B. Moynihan, Jennifer L. Mandzia, Jesús Juega, Estela Sanjuán, Debabrata Chakraborty, Chidiebere Emmanuel Okechukwu, Shengxian Tu, Christopher Levi, R Sanchez, Min Tang, Gail M. Wilkes, Gerli Sibolt, Fana Alemseged, Marie‐Christine Camden, Edward Cole, Sanchea Wasyliw, Kathryn Cawley, Saurav Das, Nawaf Yassi, Vladimir Todorov, Phavalan Rajendram, R. Azarpazhooh, Erika Teleg, E Cortijo Garcia, S K Chen, Elizabeth Pepper, T Secchi, Amin Sabet, Andrew M. Demchuk, KP McGuire, Lilian Urroz, Raeburn B Forbes, Kelly E. Courtney, María Jesús Lloret, Marta Rubiera, G. Valle Peñacoba, Karin E. Tobin, Nils Pavey, Brian H Buck, Aldi Fernandes de Souza França, Y Chin, Shorog Althubait, Gabriel Pinheiro Módolo, Alexandre Kracker Imthon, John McCabe, James Beharry, Matthew Benger, Tracey Taylor, Lourdes R. García, Victor Augusto Vera Monge, Clement Chee Yung Tham, Grant Stotts, Carolina Oldoni, Frank L. Silver, Álvaro García‐Tornel, A. Langer, Charlotte Zerna, Robert J. Hard, Helen Duffy, Anna Feliu, Timothy John Kleinig, Daniel Strbian, F Winckler, Ariane Mackey, Kathleen Ferreira, Maneesha Kamra, Rachel Teal, Herbert Alejandro Manosalva Alzate, Viveka Biswas, Aravind Ganesh, Yolanda Silva, Cary T. Hutchinson, Earl C. Harrison, Nicholar Maraj, G. L. Maclean, H Toma, John T. Benjamin, Millene Rodrigues Camilo, Selin Doğan Jamil, M. J. Sanchı́s, James Teo, Edward Littleton, Amanda Dawson, Melanie Penn, Saeed Hosseini, Marie-Andrée Panzini, Reham Shamloul, Manuel Reina, Michelle S. Min, Arthur Pille, L. Sztriha, Craig Doram, Mark Angle, Mitchell Lycett, Richard Perry, Mónica Recamán, Amy Yu, Jason W. Allen, Sana Mansoor, Sadaf Kalam, Mark Marinescu, Hemant Kamble, Lloyd Waxman, Angela Dos Santos, Sanne A. E. Peters, Andrew J. Murray, Nancy Newcommon, Ruchir Shah, Emma Taylor, N Chia, Omid Halse, Paulus Stefan Rommer, Nazeem Arsalan, Thomas Chad, Sheila Cristina Ouriques Martins, Mary D. Naylor, Marjaana Tiainen, Arumugan Nallasivan, Mikel Terceño Izaga, Thomas Fitzpatrick, M. Tan, Claire O'Hare, Dolly Singh, Susanne Macher, Mike Horton, David Williams, P Bello, Tom Wellings, Erika Manolo, Yan L. Dang, Anish Engineer, Shozeb M Haider, Shelly Bohn, Kousik Sivakumar, Nicole Blenkin, A Alrohimi, Nigel P Murray, María Bres Bullrich, Mohammed Almekhlafi, Ashkan Shoamanesh, Stephanie Reiter, Shirin Jalini, Cecilia Cabrera, Vivek P. Patel, Jessica Tsoleridis, Andrew McGovern, Alexander V. Khaw, Geraint Roberts, Rhys Williams, Stephan Blechinger, C.A. Enriquez, K. Santana, R.M. Asuncion, Andrew Williams, Urszula Bojaryn, Jelena Blagojević, Atsushi ESAKI, U Nwanguma, Keith W. Muir, Evangelia Theochari, Mathew Hannouche, Heidemarie Zach, Christopher J. Lynch, Suresh Subramaniam, Sally J. McMillan, Akshay Deepak, Nicole J. Sylvain, H C McEvoy, Sucharita Ray, Shyam Kelavkar, Lorraine Fleming, R. Ashayeriahmadabad, Michael Marnane, Lindsay Lambourn, Stuart Neilson, Dar Dowlatshahi, Mehrnoosh Pauls, Frederick W. Vonberg, Robert Fahed, Oishik Raha, Elaine Shand, K Chatterjee, Martha Marko, A‐La Park, Agnieszka Kieliszkowska, Kenneth W. Dodd, Khosrow Ghavami, Otavio Costa Vincenzi, Philip Choi, C. C. Patterson, Sze‐Yuan Ooi, Angela Southwell, Assem A. Sultan, Hayrapet Kalashyan, Aristeidis H. Katsanos, Katrina Hannah D. Ignacio, Babawale Arabambi, Alireza Nomani, Oscar Benavente, Mohamed Badawy, Sanjay Mishra, Nick Parsons, Gary Hunter, Eric Ehrensperger, J. Vieira, Brett Hughes, Ferdinand Miteff, Daniel Fabiano Barbosa dos Santos, George Harston, Masaki Tsuda, S. K. Chaturvedi, Andrew M. Penn, Aaron Gardner, Stéphanie Gosselin-Lefebvre, Santhosh Kuriakose, Brian Clarke, Olena Bereznyakova, Vivek Pravin Dave, J. Mitchell-Douglas, Tejas Patel, Ajay Bhalla, Heidi Janssen, Peter K. Stys, P Lee, Ann-Marie Liddy, Laura Pardo, Michel Christopher Frank Shamy, Nicola C. Day, Nathaniel Lizak, Lori Piquette, Sarman Singh, Federico Carpani, David Gan Eng Yeow, G Mendes, Wolfgang Series, Anna Balabanski, Chetan Vekhande, George Medvedev, U Schulz, Shabnam Vatanpour, Sandra Boned, Dennis J. McShane, Olalla Pancorbo, William Whiteley, Alessandra Braga Cruz Guedes de Morais, Frances Taylor, T. Sugumar, Orsolya Vittay, Berzenn Urbi, Johnathan Man, Shez Feerick, Nuno Cordeiro Ferreira, S. Dunkerton, Karina Villaluna, Michael Kelly, Bryan Martin, Thanh N. Nguyen, Samuel J. Stratton, Alayna E. Loiselle, Derek J. Roberts, Rick Swartz, Alexandra Muccilli, Leila Aparecida Machado Galvao Mondin, Joanne Hiden, Ashesh N. Buch, Jorge Teodoro de Souza, Nishita Singh, Anitha Jambula, Katharine Stephens, S Maley, Kailash Krishnan, Enda Kerr, Ankur Wadhwa, S Meenakshisundaram, David Williams, Rita Ghatala, Craig Kurunawai, Cai Sim, Rebecca Wiegner, Yee‐Haur Mah, RA Joundi, Aimen Moussaddy, Colin P. Hawkes, Anne O’Sullivan, Ondřej Volný, Felix Ng, Gary A. Ford, AE Black, Gustavo Saposnik, A Hedstrom, Oneil G. Bhalala, Loren Toussaint, Janka Hegedus, Christopher L. Kirkland, Ammad Mahmood, Vivian Fu, Laura White, R. Varquez, Jill Roberts, Logesh Palanikumar, Walid Alesefir, J Williamson, Neil J. Spratt, P Park, N.A. Fleck, Mohamed Farag, Peter J. Kelly, Jeanne Teitelbaum, Nihay Laham-Karam, Andrew John Davies, Shelley L. Murphy, Pardo Lozano, Vinny Naidoo, James Newham, Sushma Save, Thalia Shoshana Field, Lara Kaauwai, Karla J. Ryckborst, Sean Conway, G. Mantovani, V. Sala, Shaddy El‐Masri, Yi‐Chung Lee, S Obarey, Mia Son, Ivy Sebastian, Katie Lin, Stephen van Gaal, Phillip Ferdinand, Angela Royan, Ryan T. Muir, M Garcia Pardo, Christopher Seet, Andrew Lockey, Karlin Li, R. W. Dunning, Samuel Yip, AI Calleja Sanz, Sidhu P. Gangadharan, Bruce C.V. Campbell, Suzy Lavoie, Ana Isabel Lopez Murillo, Margaret Moores, Bektaş Sarı, Jacques Auger, Aaron Wagner, Josh King‐Robson, Adeel A. Butt, Robert Murphy, Luciana Catanese, Brendan Cord Lethebe, Bryn M. Smith, Kathleen Ward, Wolfgang Marik, B. McNamara, Subhalaxmi Dey, C. Milani, Chaoyang Ma, Karen Whittaker, Matthew Boyko, Christine Roffe, Paula Ramírez, Theresa M. Busch, Leanne K. Casaubon, Karen Sage, Ai Ling Tan, Alyson Plecash, Bikram Prasad Gajurel, Sally Ormond, John Ng, Claudine Legault, Zhiyu Ling, Kenneth Butcher, Joni Panula, Bijoy K. Menon, HM Dewey, Joseph Francis, Ramana Appireddy, Silja Räty, Shahnaz Gauhar, Luca Zanella, Tia Chakraborty, Lauren Binnie, Andréia Martini Pazini, Karen Roberts, Demetrios J. Sahlas, Carlos Massote Fontanini, Christopher Tyson, F. Boyle, Steve Verreault, Lisa Crellin, Darren Tse, F. A. Dias, Suzanne Mitchell, Peter Bailey, Arunima Kapoor, Mark William Parsons, Branko Borojevic, Adam Lewis, Angela Moore, O Suomalainen, Joseph Kwan, M Aissa, Leka Sivakumar, George Thomas, Juan F. Arenillas, Joanne Joseph, Juline Jabs, Sherwin J. U. Agustin, Karine Collard, Philip A. Barber, Rodrigo Bazán, Nadia Francia, Brendan Drumm, N Martinez Majander, Diana J. Day, Idris Fatakdawala, Cha‐Nam Shin, N Stuart, Mark I. Boulos, Dorothy H. Crawford, Robert Simister, Ahmad Nehme, Ruaridh Cameron Smail, Rana Alnasser Alsukhni, Alaae Boutayeb, Denise Vasquez, Bruna Cristine Chwal, Robson Sarmento Teodoro, Tao Yu, David John Werring, Grant W. Edmonds, R Lee, Stefan Greisenegger, Bonny Granfield, Sajida Kazi, Sudhir Tauro, Jorge Pagola, Teddy Y. Wu, Jeyaledchumy Mahadevan, Kimberley Foster, Atif Zafar, Miguel Del Campo, Lavenia Cagi, KarthickT Nadar, Farhana Akthar, M. Baumgartinger, Rowena Singkang, S. Eirola, Naomi Priestley, Naila Pachani, Sonja Wieszmuellner, Michele Demetroff, Rebeccah Beardshaw, Dylan Blaquiere, Bismah Ghoari, M.A. Hamind, Robert Samiento, Nadia Ben-Amor, Anna Gisold, Terhi Ivanoff, Anu Erakanto, Laura-Leena Kupari, Linda Belevski, Laura Fisicchia, Davor Pavlin-Premri, V. Sapaen, M Mozhy Mahizhnan, R. R Siew, A. d'Emden, Cyrille Cahoy, Georgia Raingold, Ndifreke Atang, Monica Jhoots, Susan Cotgreave, T. Matar, Nicholas Winterkron, Narmathey Thanbirajah, Jim McIImoyle, Lucie Dews, Susan Heeley, Maria Tibajia, Samantha Bayhonan, Dimitrios Nouvakis, Puja Punjabivaryani, Luana Aparecido Muondo Bonome, Andrew Micielli, Qiao Zhang, Shuo Chen, Jianjun Liu, Jiang He, Do Young ‍Kim, Andrew Lee, Jingwen Chen, Aihua Liu, Michael D. Hill, Jungwha Julia Lee, Ángela Sánchez‐Algaba Gómez, J.Z.W. Wong, V.A. Cury Silva, Matthew Russell, Stefan Krebs, Rui Martins, A. Jin, Edward Fox, Albert V. Smith, Carlos A. Molina, Laura Wilson, Wendy M. Smith, Shiyu Hu, Rezaul Karim, Rodrigo Fuentes, Nandita Shenoy, David M. Jackson, M Anonuevo Reyes, Ana Leticia Amorim de Albuquerque, Claire Buchanan, Richard H. Drew, Donatella Tampieri, M. A. Saeed, Mina K. Chung, Chrysi Bogiatzi, Asim A. Sheikh, Caroline Domingos Belo, Julia J. Hopyan, F J Reyes Munoz, Guilherme Gualberto Rodrigues, Marjorie Ariele Pereira, C.F. Matinez Rubio, F.F.A. Alves, Joao Paulo de Queiroz, J. Kennedy, John Wong, R Whelan, J. M. Koski, Dolar Doshi, Geevar Zachariah, M Sayed, Evgenia Klourfeld, P. Teal, L. D. Smith, David José, S Nagendra, Paul Fearon, Julio Cesar dos Santos Moreira, C Kenney, Arline McDonald, Gary Klein, Klaus Werner, Mohammed Ismail, M Cortes, Vanessa Norouzi, E Rodrigues, R. Sanyal, J. Elliot, Carol Kenney, N. Ishaque, Angela Welch, Maurizio R. Soma, Mary H. Doheny, A. Robinson, Oje Imoukhuede, Renee Martin, Nathalie Bason, Wing Kin To, PrasannaVenkatesan Eswaradass, L Kalman, M Matthew, PA Barber, H Bains, Chris Linton, A. Banaras, Raulle Sol Cruz, M. Bates, S Leason, J Aeron‐Thomas, Kala Bolt, K Isaacs, Matti Ahlström, Javier Reyes, G. Silva, P. Gordon, B. Dewar, K.Y. Law, G Noll, M.F. Chung, J. Grimley Evans, J.S. Brar, Karen To, R Cooley, Don Sims, L. Mai, Susheel K. Malani, Simerpreet Bal, Clare Williams, Kathleen A. Kennedy, M. De Lera Alfonso, Mark E. Ramos, Beth Beauchamp, P Couillard, I. H. Jenkins, R Muhammad, L. A. Sebastian, S. Ankolekar, Michael Kwan, Amy Ashton, J Rodríguez, Virendra Bhandari, D. Selchen, A. Haber, O Neto, D Lopez Dominguez, Abdel-Ghanny M El-Masry, Ashley Dueck, S Heller, K Boyle, Kayla V Lucas, A Sitaram, Bárbara Gómez, N Ike, Peter Wilding, Linda Quinn, Davi Teixeira dos Santos, B Graham, S Lawrence, Konrad Nowak, Noelia Rodríguez, B Joseph, Christine McCarthy, Brunna Rimoli, O. Dale Williams, E.P. Callaly, Bruno Pegorer Santos, C Brown, Thomas J. Webster, David J. Gladstone, S Weatherb, Quinten Collier, Primary Study Coordinators
article en
1 citations

Abstract

Tenecteplase was not associated with better clinical outcomes over nonthrombolytic control in female or male patients with minor ischemic stroke, despite more frequent recanalization. Fewer women treated with tenecteplase returned to baseline function compared with men.

Journal of the American Heart AssociationVol. 14(9)
Royal Adelaide Hospital (AU), Sunnybrook Health Science Centre (CA), University of British Columbia (CA), University of Alberta (CA), The University of Melbourne (AU), University of Calgary (CA), Queen's University (CA), Australian Regenerative Medicine Institute (AU), Health Sciences Centre (CA), Eastern Health (AU), Monash University (AU), The University of Adelaide (AU), University of Glasgow (GB)
Good health and well-being
Openalex Percentile: Top 21%
Acute Ischemic Stroke Management
1.35
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.