Endothelial Cell Senescence in Marfan Syndrome: Pathogenesis and Therapeutic Potential of TGF‐β Pathway Inhibition
This study highlights the pivotal role of endothelial cell senescence in the pathogenesis of aortic aneurysms in MFS. Our human induced pluripotent stem cells-based disease model provides new insights into the disease mechanisms and underscores the potential of targeting the transforming growth factor-beta pathway to mitigate endothelial dysfunction and senescence, offering a promising therapeutic avenue for MFS.
Authors
- Runze Dong (ORCID: https://orcid.org/0000-0002-7294-3070)
- Yongyu Wang (ORCID: https://orcid.org/0000-0002-6088-8887)
- Xiaofang Fan (ORCID: https://orcid.org/0000-0002-7234-0093)
- Yuankang Zhu
- Yongsheng Gong (ORCID: https://orcid.org/0000-0001-6492-7030)
- Xu Yubin
- Ming Li (ORCID: https://orcid.org/0000-0002-7699-4502)
- Mi Zhou (ORCID: https://orcid.org/0000-0001-8144-3468)
- Lu Ding (ORCID: https://orcid.org/0000-0002-1966-4080)
- Xiufang Chen (ORCID: https://orcid.org/0000-0002-8795-6923)
- Peifeng Jin (ORCID: https://orcid.org/0000-0001-9840-7180)
- Xiaoli Ren (ORCID: https://orcid.org/0009-0005-1656-0840)
- Yuhao Chen (ORCID: https://orcid.org/0009-0003-0576-4712)
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- XinHua Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1161/jaha.124.037826
- Citations
- 7
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 12.72