Hypothalamic Gliosis Is Associated With Multiple Cardiovascular Disease Risk Factors in the Framingham Heart Study
Using a well-established study of cardiovascular disease development, we found evidence linking hypothalamic gliosis to multiple cardiovascular disease risk factors, independent of adiposity. Our results highlight the need to consider central nervous system mechanisms to understand and improve cardiometabolic health.
Authors
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Ellen A. Schur (ORCID: https://orcid.org/0000-0002-1013-0795)
- Kelsey Olerich
- Susan J. Melhorn (ORCID: https://orcid.org/0000-0001-7969-8496)
- Sarah Kee
- Alexa S. Beiser (ORCID: https://orcid.org/0000-0001-8551-7778)
- Alyssa Huang (ORCID: https://orcid.org/0000-0003-0603-5485)
- Charles DeCarli (ORCID: https://orcid.org/0000-0003-1914-2693)
- Dabin Yeum (ORCID: https://orcid.org/0000-0001-9575-4849)
- Justin Lo (ORCID: https://orcid.org/0000-0003-2145-6528)
Institutions
- The University of Texas at San Antonio Health Science Center (US)
- University of Washington (US)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1161/jaha.124.039463
- Citations
- 1
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.91