Glycodeoxycholic acid alleviates central precocious puberty by modulating gut microbiota and metabolites in high-fat diet-fed female rats
This study demonstrates that GDCA exhibits a potential therapeutic effect on CPP through a unique mechanism that involves gut microbiota modulation, alterations in serum metabolites, and changes in the expression of key regulatory factors Sirt1.
Authors
- M Zhang (ORCID: https://orcid.org/0009-0003-3711-8256)
- Yanan Liu (ORCID: https://orcid.org/0000-0002-7136-6777)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-4284-2604)
- Nan Wu (ORCID: https://orcid.org/0000-0002-3531-1656)
- Ning Li (ORCID: https://orcid.org/0000-0002-1519-4552)
- Fei Chen (ORCID: https://orcid.org/0000-0003-3895-6318)
- Qinghua Wang (ORCID: https://orcid.org/0009-0007-1535-0870)
- Wei Wu (ORCID: https://orcid.org/0000-0002-9044-0901)
- Xin Jiang (ORCID: https://orcid.org/0009-0004-1070-9141)
- Min Yue
Institutions
- Shandong University (CN)
- University of California, Santa Cruz (US)
- University of Jinan (CN)
- Jinan Maternity And Care Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s00018-025-05680-2
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Shandong University
- National Natural Science Foundation of China
- Chinese Center for Disease Control and Prevention
- Natural Science Foundation of Shandong Province
- Centers for Disease Control and Prevention