Monitoring subcellular NADP redox state with NAPstar biosensors
NADP is a crucial coenzyme in all living organisms, fulfilling important and distinct functions in different subcellular compartments. The NADP redox state is intimately coupled to anabolic metabolism, antioxidative defence, and signalling. However, reliable and specific monitoring of subcellular NADP redox state dynamics has proven remarkably challenging. The NAPstar family of genetically encoded fluorescent NADP redox state probes overcomes key limitations of previous approaches.
Authors
- Letícia Prates Roma (ORCID: https://orcid.org/0000-0001-9527-0529)
- Jan Riemer (ORCID: https://orcid.org/0000-0002-7574-8457)
- Markus Schwarzländer (ORCID: https://orcid.org/0000-0003-0796-8308)
- Jan-Ole Niemeier (ORCID: https://orcid.org/0000-0002-4081-8101)
- Bruce Morgan (ORCID: https://orcid.org/0000-0001-9393-1071)
Institutions
- University of Münster (DE)
- Institute of Plant Biology and Biotechnology (KZ)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Saarland University (DE)
Publication Details
- Journal
- Trends in Biochemical Sciences
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1016/j.tibs.2025.03.013
- Citations
- 2
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 1.46
Funders
- Deutsche Forschungsgemeinschaft
- Universität des Saarlandes