Regulatory T cell epitope content in human antibodies decreases during maturation
The correlation of Tregitope depletion with increasing SHM implies that the activity of thymus-derived Treg cells in immune responses to antibodies is diminished with SHM, maturation, and isotype switching, supporting the generation of anti-idiotype responses.
Authors
- Andrés H. Gutiérrez (ORCID: https://orcid.org/0000-0002-6127-8327)
- William Martin (ORCID: https://orcid.org/0000-0001-8694-494X)
- Anne S. De Groot (ORCID: https://orcid.org/0000-0001-5911-1459)
- Frances Terry (ORCID: https://orcid.org/0000-0002-8670-4310)
- Amy S. Rosenberg
Institutions
- Providence College (US)
- EpiVax (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1535826
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harvard University
- National Cancer Institute