Correlation between gene polymorphisms and perioperative analgesia in patients undergoing gynecological surgery
Patients with GG and AG genotypes of <i>OPRM1 rs1799971</i> gene required more 24-h postoperative analgesics after gynecological surgery compared to those with AA genotype. A SNP-SNP interaction was observed between <i>OPRM1 rs179971</i> and <i>CYP450 3A4 * 1G rs2242480</i>. <b>Clinical Trial Registration:</b> (www.chictr.org.cn, registration number: ChiCTR2200062425).
Authors
- Meng Cai
- Xiaofeng Lei (ORCID: https://orcid.org/0000-0001-9290-9198)
- Lin Gan (ORCID: https://orcid.org/0000-0001-5278-4554)
- Yu Jin (ORCID: https://orcid.org/0000-0002-5040-0497)
- Jing Li (ORCID: https://orcid.org/0000-0002-4763-9261)
Institutions
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fgene.2025.1509042
- Primary Topic
- Cardiac, Anesthesia and Surgical Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Chongqing
- Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission