BTG2-deficient mast cells remodel the tumor and tumor-draining lymph node microenvironment leading to chemotherapy resistance in breast cancer
This study highlights the immunoregulatory role of mast cells in the breast cancer tumor microenvironment and establishes a link between BTG2 expression in mast cells and neoadjuvant chemotherapy response. These findings provide a foundational basis for preserving functional lymph nodes and optimizing combined radiotherapy treatment strategies.
Authors
- Jiahuai Wen (ORCID: https://orcid.org/0000-0001-7326-5980)
- Mengling Kang
- Ziyu Liu (ORCID: https://orcid.org/0000-0002-7302-0024)
- Xiaoqian Zhang (ORCID: https://orcid.org/0000-0001-5907-9233)
- Jiayi Wang (ORCID: https://orcid.org/0000-0003-1688-2864)
- Fang Chen (ORCID: https://orcid.org/0000-0002-7681-6917)
- Ren Li-ping (ORCID: https://orcid.org/0000-0002-7373-5580)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1562700
- Citations
- 1
- Primary Topic
- Cancer-related gene regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81