An evaluation of novel AMP2-coated electrospun composite scaffolds for intraoral bone regeneration: a proof-of-concept in vivo study
Compared to defects treated with porcine-derived particulate and barrier membrane (CTRL), defects filled with OA exhibited bone regeneration throughout the defect, with bone overgrowth when covered by a barrier membrane at 4-weeks <i>in vivo</i>. This suggests that the novel combination of AMP-2 and a bioceramic/synthetic polymer-based electrospun scaffold is a suitable candidate for GBR procedures, without a barrier membrane to secure its place within a defect.
Authors
- Blaire V. Slavin (ORCID: https://orcid.org/0000-0002-0933-9778)
- Nicholas A. Mirsky (ORCID: https://orcid.org/0009-0005-0941-6605)
- Kihwan Hwang (ORCID: https://orcid.org/0000-0001-7211-729X)
- Vasudev Vivekanand Nayak (ORCID: https://orcid.org/0000-0003-2739-0339)
- Lukasz Witek (ORCID: https://orcid.org/0000-0003-1458-6527)
- Paulo G. Coelho (ORCID: https://orcid.org/0000-0001-8347-6124)
- Savanah R. Sturm
- Ricky Almada
- Shangtao Wu (ORCID: https://orcid.org/0009-0002-7839-0419)
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- New York University (US)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fbioe.2025.1443280
- Citations
- 3
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 2.02