CD19+ B cell depletion: a novel strategy to alleviate ischemic stroke damage
Temporary inhibition of B-cell activity via aCD19 antibody injection alleviated ischemic brain injury in a mouse model of stroke by suppressing systemic immune reactions. Changes in immune cells within the meninges may play a role, and further investigation is needed to understand the mechanisms involved. These findings suggest that cerebral and systemic immune responses contribute to the pathogenesis of ischemic stroke, and temporary B cell depletion may represent a potential therapeutic target for stroke therapy.
Authors
- Min Gao (ORCID: https://orcid.org/0000-0003-0127-7477)
- Lamei Cheng (ORCID: https://orcid.org/0000-0002-8685-3674)
- Yizhong Yan (ORCID: https://orcid.org/0000-0003-1957-5421)
- Jing Peng (ORCID: https://orcid.org/0000-0002-7752-6962)
- Hongjing Zang (ORCID: https://orcid.org/0009-0001-9713-6523)
- Yu Xu (ORCID: https://orcid.org/0000-0002-0574-1460)
- Yu Zhou (ORCID: https://orcid.org/0000-0001-9369-2082)
Institutions
- Central South University (CN)
- National Engineering Research Center of Human Stem Cells (CN)
- Second Xiangya Hospital of Central South University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1528471
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province