Serotonin-norepinephrine reuptake inhibitor and gabapentinoid use independently predict greater postoperative opioid consumption in lumbar fusion patients
A complex relationship exists between the medical management of mood disorders and neuropathic pain using antidepressants, anxiolytics, and gabapentinoids for patients undergoing spinal surgery. Patients prescribed gabapentinoids and SNRIs are at increased risk of opioid use postoperatively while patients taking SSRIs do not demonstrate such increased risk.
Authors
- Michael A. McCurdy (ORCID: https://orcid.org/0009-0005-5116-515X)
- David M. Kaye (ORCID: https://orcid.org/0000-0003-4058-0372)
- Alexa Tomlak (ORCID: https://orcid.org/0009-0007-8523-2183)
- José A. Canseco (ORCID: https://orcid.org/0000-0002-2152-5725)
- Christopher K. Kepler (ORCID: https://orcid.org/0000-0002-0996-4346)
- Mark F. Kurd (ORCID: https://orcid.org/0000-0001-9680-1088)
- John J. Mangan (ORCID: https://orcid.org/0000-0003-4408-1036)
- Tariq Z. Issa (ORCID: https://orcid.org/0000-0002-0978-5225)
- Kenneth L. McCall (ORCID: https://orcid.org/0000-0003-2061-108X)
- Alan S. Hilibrand (ORCID: https://orcid.org/0000-0001-8811-9687)
- Robert J. Oris (ORCID: https://orcid.org/0000-0001-8743-0860)
- Jonathan Dalton (ORCID: https://orcid.org/0000-0002-7452-2712)
- Yunsoo Lee (ORCID: https://orcid.org/0000-0002-6039-5142)
- Gregory D Schroeder
- Alexander R Vaccaro
- Rajkishen Narayanan
- Dodger Norceide
Institutions
- Rothman Institute (US)
Publication Details
- Journal
- European Spine Journal
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s00586-025-08764-6
- Citations
- 3
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 6.02