Acetyl-CoA synthetase 2 alleviates brain injury following cardiac arrest by promoting autophagy in brain microvascular endothelial cells
Our study shows that ACSS2 modulates the biological functions of BMVECs by promoting autophagy. Enhancing energy metabolism via ACSS2 may target PCABI treatment development.
Authors
- Xin Yu (ORCID: https://orcid.org/0000-0002-6823-9312)
- Jiawei Tao
- Lin Yao (ORCID: https://orcid.org/0000-0003-1027-4219)
- Xiangkang Jiang
- Jiefeng Xu (ORCID: https://orcid.org/0000-0001-5597-0838)
- Chenghao Wu (ORCID: https://orcid.org/0000-0002-6515-0988)
- Ziwei Chen (ORCID: https://orcid.org/0009-0001-8242-3853)
- Mao Zhang (ORCID: https://orcid.org/0000-0001-7919-8213)
- Wenbin Zhang (ORCID: https://orcid.org/0000-0002-7681-7530)
- X Zhang (ORCID: https://orcid.org/0000-0002-4686-2840)
- Jiantao He
- Ruojie Zhu
Institutions
- Zhejiang Chinese Medical University (CN)
- Zunyi Medical University (CN)
- Zhejiang Medical and Health Group Hangzhou Hospital (CN)
- Communication University of Zhejiang (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Cellular and Molecular Life Sciences
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s00018-025-05689-7
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National Natural Science Foundation of China