Ceftolozane/tazobactam use and emergence of resistance: a 4-year analysis of antimicrobial susceptibility in Pseudomonas aeruginosa isolates in a tertiary hospital
The unavailability of C/T created the conditions to analyze the practical application of the theory of fitness cost to maintain resistance. A subsequent increase after a first reduction in C/T resistance rate was observed, probably due to persistence of resistant isolates and antibiotic selective pressure. Continuous monitoring of antibiotic use and evolving resistance is essential.
Authors
- Marco Iannetta (ORCID: https://orcid.org/0000-0002-6938-8627)
- Loredana Sarmati (ORCID: https://orcid.org/0000-0003-1452-0333)
- Cartesio D’Agostini (ORCID: https://orcid.org/0000-0001-9199-3340)
- Laura Campogiani (ORCID: https://orcid.org/0000-0002-7462-169X)
- Andrea Di Lorenzo (ORCID: https://orcid.org/0009-0008-1772-196X)
- Massimo Andreoni (ORCID: https://orcid.org/0000-0002-3205-9758)
- María Celeste
- Alessandra Imeneo
- Anna Altieri
- Pietro Vitale (ORCID: https://orcid.org/0009-0009-9563-0964)
- Vincenzo Malagnino (ORCID: https://orcid.org/0000-0002-6561-5298)
- Davide Natale Abate
- Grazia Alessio
Institutions
- University of Rome Tor Vergata (IT)
- Policlinico Tor Vergata (IT)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fmicb.2025.1542491
- Citations
- 3
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 1.77