TGFB1/CXCL5 axis regulation by LCN2 overexpression: a promising strategy to inhibit colorectal cancer metastasis and enhance prognosis
This study underscores LCN2 as an independent protective factor and prognostic biomarker for CRC patients. Combined treatment with the SB431542 and the SB225002 significantly attenuated LCN2-related CRC metastasis. Targeting the LCN2/TGFB1/CXCL5 axis emerges as a promising therapeutic strategy for managing LCN2-related metastatic CRC.
Authors
- Yanxin An
- Pengfei Yu (ORCID: https://orcid.org/0000-0002-1881-1245)
- Dan Song (ORCID: https://orcid.org/0000-0002-2417-9899)
- Bin Bai (ORCID: https://orcid.org/0000-0001-9904-9987)
- Song Xiaotian
- Juan Wang (ORCID: https://orcid.org/0000-0001-9745-6087)
- Shiqi Wang (ORCID: https://orcid.org/0000-0002-2381-044X)
- Shuai Xu (ORCID: https://orcid.org/0000-0002-2220-7243)
- Qingchuan Zhao (ORCID: https://orcid.org/0000-0002-2132-7817)
- Bin Yang (ORCID: https://orcid.org/0000-0002-7022-4822)
Institutions
- Wuhan University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Xi'an Medical University (CN)
- Renmin Hospital of Wuhan University (CN)
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1548635
- Citations
- 3
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42