Multiplex immunophenotyping of human acute myeloid leukemia patients revealed single -cell heterogeneity with special attention on therapy sensitive and therapy resistant subpopulations
This study focused on understanding the LAIP in AML before and after therapeutic intervention. The study highlights the potential of using single-cell LAIP profiling and immune mediator measurements to monitor therapy response and identify measurable residual disease and therapy resistant cell populations in AML.
Authors
- László Krenács (ORCID: https://orcid.org/0000-0001-9509-6575)
- Gábor J. Szebeni (ORCID: https://orcid.org/0000-0002-6998-5632)
- Nikolett Gémes (ORCID: https://orcid.org/0000-0003-2028-1666)
- Benedek Rónaszéki (ORCID: https://orcid.org/0000-0002-7689-9361)
- Zsuzsanna László
- Szabolcs Modok
- Enikő Bagdi
- Enikő Szabó (ORCID: https://orcid.org/0000-0002-7701-8861)
- Valeria Bertagnolo (ORCID: https://orcid.org/0000-0002-4742-2302)
- Balázs Csernus (ORCID: https://orcid.org/0000-0002-9862-2160)
- Imre Földesi
- László G. Puskás
- Zita Borbényi
- Éva Trucza
- Blanka Godza
Institutions
- Semmelweis University (HU)
- University of Ferrara (IT)
- University of Szeged (HU)
- HUN-REN Szegedi Biológiai Kutatóközpont (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1563386
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00