Prenatal opioid exposure alters pain perception and increases long-term health risks in infants with neonatal opioid withdrawal syndrome
The identified methylation alterations may shed light on pain, neurodevelopmental changes, and other biological mechanisms in opioid-exposed infants and mothers with OUD, offering insights into NOWS and maternal-infant health. These findings may also pave the way for targeted interventions and improved pain management, highlighting the potential for integrated care strategies to address the interconnected health of mothers and infants.
Authors
- Lavanya V. Uppala (ORCID: https://orcid.org/0000-0002-5459-4217)
- Srinivas B. Muvvala (ORCID: https://orcid.org/0000-0003-2766-2074)
- Uppala Radhakrishna (ORCID: https://orcid.org/0000-0002-6617-5634)
- Rakesh Rawal (ORCID: https://orcid.org/0000-0002-7985-1187)
- Tithi S. Trivedi (ORCID: https://orcid.org/0000-0002-7040-3003)
- Ray Bahado‐Singh
- Senthilkumar Sadhasivam (ORCID: https://orcid.org/0000-0002-3689-8313)
- Jignesh Prajapati (ORCID: https://orcid.org/0000-0001-8700-9929)
- Rupa Radhakrishnan (ORCID: https://orcid.org/0000-0001-5224-1891)
Institutions
- Gujarat University (IN)
- Creighton University (US)
- University of Pittsburgh (US)
- Yale University (US)
- Beaumont Hospital, Royal Oak (US)
- Gujarat Biotechnology University
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Frontiers in Pain Research
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fpain.2025.1497801
- Citations
- 1
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 3.49