Shank3 mutation manifests in abnormal gastrointestinal morphology and function in mice
<i>Shank3B<sup>-/-</sup></i> mice exhibit altered GI morphology and function, while <i>Shank3B<sup>+/-</sup></i> mice exhibit a partial phenotype. These results indicate that <i>Shank3,</i> whose mutation is associated with ASD, is critical for function of the GI tract and its mutation may contribute to the etiology of GI comorbidities.
Authors
- Hadi Hussein (ORCID: https://orcid.org/0009-0000-9146-9397)
- Polina Anikeeva (ORCID: https://orcid.org/0000-0001-6495-5197)
- Marie Manthey
- Karen Ka Lam Pang
- Emmanuel Vargas Paniagua
- Gari Liu Eberly
- Scott Machen
- Sara Maeve Klingensmith
Institutions
- McGovern Institute for Brain Research (US)
- Wellesley College (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Frontiers in Neuroscience
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fnins.2025.1552369
- Citations
- 4
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- National Science Foundation
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- National Institutes of Health
- McGovern Institute for Brain Research, Massachusetts Institute of Technology