Bee venom ameliorates gentamicin-induced kidney injury by restoring renal aquaporins and enhancing antioxidant and anti-inflammatory activities in rats
BV mitigated the GM-inflicted kidney damage, as evidenced by a substantial improvement in the renal function and oxidative state. In addition, a downregulation in the expression of inflammatory biomarkers (Casp-1, IL-6, TNF-α, and NF-κB/P65/P50) and an upregulation of oxidative stress marker expression (NRF2) were noticed. BV upregulated the expression of aquaporins (AQPs) and renal water channel proteins (AQP1 and AQP2), which are useful for the early detection of renal injury. Additionally, BV exposure exerted a mitigating effect on the apoptotic cascade, as evidenced by the downregulation of cleaved Caspase-3 (Casp-3) and cytochrome c (Cyto c). BV administration also led to an improvement in RBC, WBC, and platelet counts, along with enhanced Hb levels. Interestingly, BV could protect against GM triggered nephrotoxicity.
Authors
- Afaf Abdelkader (ORCID: https://orcid.org/0000-0002-0460-3402)
- Mohamed Gamal Elsehrawy (ORCID: https://orcid.org/0000-0001-9887-3907)
- Zainab M. Maher
- Samah Fathy Ibrahim (ORCID: https://orcid.org/0000-0002-2824-3296)
- Laila Mostafa
- Mohamed Elsayed Mohamed Mohamed (ORCID: https://orcid.org/0000-0002-9037-0253)
- Obeid Shanab (ORCID: https://orcid.org/0000-0003-1981-279X)
- Moaz Mojaddidi (ORCID: https://orcid.org/0000-0002-1221-4597)
- Doaa Abdelrahaman
- Ahmed Badawy (ORCID: https://orcid.org/0000-0002-4966-3839)
- Naglaa Mokhtar (ORCID: https://orcid.org/0000-0002-8364-1238)
- Khalid M. Elazab (ORCID: https://orcid.org/0000-0002-2687-6735)
- Dania Abdelhady
- Yasser M. Elbastawisy
- Madaniah O. Zakari (ORCID: https://orcid.org/0009-0008-2232-1987)
- Ahmed Abdeen
- Amal S. Abu-Almakarem
- Hagar Kouriem
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Northern Border University (SA)
- Alfaisal University (SA)
- Prince Sattam Bin Abdulaziz University (SA)
- Mansoura University (EG)
- South Valley University (EG)
- Benha University (EG)
- Taibah University (SA)
- Al-Ghad International Health Sciences Colleges (SA)
- Dubai Medical College (AE)
- Almaarefa University
- Al Baha University (SA)
- Port Said University (EG)
- Jazan University (SA)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fphar.2025.1525529
- Citations
- 7
- Primary Topic
- Healthcare and Venom Research
- Type
- article
- Field-Weighted Citation Impact
- 9.76
Funders
- AlMaarefa University
- Princess Nourah Bint Abdulrahman University