Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway
This study suggests that eosinophils and pleural macrophages cooperatively regulate eosinophilic airway inflammation via 12/15-LOX expression. Targeting 12/15-LOX metabolism in these cells may offer new therapeutic strategies for severe asthma.
Authors
- Tetsuya Hosaka (ORCID: https://orcid.org/0000-0003-0302-2275)
- Yosuke Isobe (ORCID: https://orcid.org/0009-0001-1043-0042)
- Jun Miyata (ORCID: https://orcid.org/0000-0002-3189-1702)
- Makoto Arita (ORCID: https://orcid.org/0000-0001-9902-0463)
- E. Ito (ORCID: https://orcid.org/0009-0001-0785-0679)
- Tsuyoshi Yamane
- Reika Hayashizaki
Institutions
- Keio University (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1565670
- Citations
- 2
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Japan Agency for Medical Research and Development
- Ono Medical Research Foundation
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency
- RIKEN
- Exploratory Research for Advanced Technology