Integrative genomic analysis and diagnostic modeling of osteoporosis: unraveling the interplay of autophagy, osteogenesis, adipogenesis, and immune infiltration
This comprehensive study established a network of OP-associated genes, and provides insights into the molecular mechanisms involving immune responses in OP. It identified key diagnostic genes and analyzed immune cell infiltration to better understand OP pathogenesis. The study underscores the importance of personalized treatment and the potential role of immune modulation in managing OP.
Authors
- Shuo Yang (ORCID: https://orcid.org/0000-0001-6894-0793)
- Haoran Liu (ORCID: https://orcid.org/0000-0001-8216-3679)
- Jingchun Zhu (ORCID: https://orcid.org/0000-0003-4075-431X)
- Xiaosheng Lin
- Lanlan Han
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Shenzhen Bao'an District People's Hospital (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fmed.2025.1544390
- Citations
- 1
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Shenzhen Municipal Science and Technology Innovation Council