Comprehensive molecular analyses of an autoimmune-related gene predictive model and immune infiltrations using machine learning methods in intracranial aneurysma
The results of bioinformatics analysis in our study elucidated the mechanism of intracranial aneurysm (IA), identifying two key differential genes. Our research highlights the significant roles of immune infiltration and the regulatory networks between genes, miRNAs, and drugs in IA. These findings not only enhance our understanding of the pathogenesis of IA but also suggest potential new avenues for its treatment.
Authors
- Yuying Zhao
- Zhuobo Zhang (ORCID: https://orcid.org/0000-0003-1845-9285)
- Minxue Zhang
- Zhan Liu (ORCID: https://orcid.org/0000-0003-3367-3204)
- Ling Zhou (ORCID: https://orcid.org/0000-0002-6805-2961)
- Yanling Wang (ORCID: https://orcid.org/0000-0002-1459-2268)
Institutions
- Harbin Medical University (CN)
- Fourth Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fimmu.2025.1531930
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84