α-Mangostin prevents diabetic cardiomyopathy by inhibiting oxidative damage and lipotoxicity through the AKT–FOXO1–CD36 pathway
Using both <i>in vitro</i> and <i>in vivo</i> DCM models, our study demonstrates that A-MG reduces lipid accumulation and excessive mitochondrial β-oxidation while enhancing antioxidant capacity. These results suggest that A-MG may be a novel therapeutic option for DCM.
Authors
- Qian Du (ORCID: https://orcid.org/0000-0001-8354-7500)
- Jiaojiao Xu (ORCID: https://orcid.org/0000-0001-5436-3059)
- Ping Ma (ORCID: https://orcid.org/0009-0003-7246-3143)
- Ziqian Zhang (ORCID: https://orcid.org/0000-0001-9294-660X)
- Lei Chen (ORCID: https://orcid.org/0000-0001-5857-7812)
- Miao Zhang (ORCID: https://orcid.org/0000-0003-4912-2570)
- Xue Bai (ORCID: https://orcid.org/0000-0002-4608-2510)
- Jianhong Yang (ORCID: https://orcid.org/0000-0003-3939-6471)
- Keting Dong
Institutions
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.3389/fphar.2025.1566311
- Citations
- 5
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 6.47
Funders
- Chinese Academy of Sciences
- University of Chinese Academy of Sciences
- Fundamental Research Funds for the Central Universities