miR-130a-5p/TFPI2 axis promotes invasion of hepatocellular carcinoma by altering epithelial-to-mesenchymal transition
miR-130a-5p binds to TFPI2 mRNA and promotes HCC cell migration, invasion, and xenograft tumor growth by regulating the EMT process. These findings suggest that the miR-130a-5p/TFPI2 axis may represent a promising therapeutic target for the treatment of HCC.
Authors
- Zijun Zhao (ORCID: https://orcid.org/0000-0002-9417-0224)
- Wei Wang (ORCID: https://orcid.org/0000-0002-9485-583X)
- Xiaoyuan Gu
- Weiqiang Zhang (ORCID: https://orcid.org/0000-0002-7278-5033)
- Hongmin Lu (ORCID: https://orcid.org/0000-0003-0079-7059)
- Xinyuan Lu
Institutions
- Renji Hospital (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1007/s12672-025-02296-7
- Citations
- 1
- Primary Topic
- MicroRNA in disease regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.94