Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy
In a rat model of HFD-induced T2DM that is consistent with the natural history and pathological features of NPDR, proteomics and bioinformatics analyses identified FABP3, TINAGL1, and COL4A3 as the 3 key upregulated proteins in retinas for the first time. These findings are supported by technical and clinical validations and provide novel targets for NPDR intervention.
Authors
- ZiLong Feng
- Bojie Hu (ORCID: https://orcid.org/0000-0001-7840-8290)
- Yumin Zhang (ORCID: https://orcid.org/0000-0001-5437-5973)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-2050-6343)
- Siqiong Bai
- Xinxin Pang (ORCID: https://orcid.org/0000-0001-7171-2521)
Institutions
- Tianjin Medical University Eye Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s501318
- Citations
- 1
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.71
Funders
- Tianjin Medical University
- Tianjin Medical University Eye Hospital