Effect of Lung Microbiota on Prognosis in Patients with Severe Intra-Abdominal Infection Complicated with ARDS

目的：探讨青岛地区人群重症腹腔感染合并急性呼吸窘迫综合征(ARDS)患者肺部微生态对预后的影响。方法：收集符合纳入标准的2021年6月至2022年5月青岛市立医院东院区重症监护室重症腹腔感染合并急性呼吸窘迫综合征患者肺泡灌洗液，采用2bRAD-M微生物多样性分析技术对样本进行基因检测，与2bRAD数据库对比，分析肺部微生态对预后的影响。结果：依照纳入和排除标准，共11例腹腔脓毒症患者纳入分析。根据患者预后情况分为3组：A组(存活组4例)，B组(放弃治疗组3例)，C组(死亡组4例)。结论：通过比较重症腹腔感染合并ARDS患者A组与C组发现，两组患者肺部微生态存在差异，并且存活组相较于死亡组肺部微生态结构较复杂。Objective: To investigate the effect of lung microbiota on the prognosis of patients with severe abdominal infection complicated with acute respiratory distress syndrome (ARDS) in Qingdao. Methods: Alveolar lavage fluid from patients with severe abdominal infection complicated with acute respiratory distress syndrome in the intensive care unit of Qingdao Municipal Hospital East Campus from June 2021 to May 2022 who met the inclusion criteria were collected, and the samples were genetically tested using 2bRAD-M microbial diversity analysis technology, and compared with the 2bRAD database, the impact of lung microbiota on prognosis was analyzed. Results: According to the inclusion and exclusion criteria, a total of 11 patients with intra-abdominal sepsis were included in the analysis. According to the prognosis of the patients, they were divided into three groups: group A (4 cases in the survival group), group B (3 cases in the abandonment group), and group C (4 cases in the death group). Conclusion: By comparing group A and group C of patients with severe abdominal infection complicated with ARDS, it was found that there were differences in the lung microbiota between the two groups, and the lung microbiota structure of the survival group was more complex than that of the death group.