Repeated administration of L-alanine to mice reduces behavioural despair and increases hippocampal mammalian target of rapamycin signalling: Analysis of gender and metabolic effects
Our data suggest that L-alanine may have antidepressant-like effect that may involve the modulation of glutamate neurotransmission independently of metabolism. In major depression, therefore, elevated L-alanine may be a homeostatic response to pathophysiological processes, though this will require further investigation.
Authors
- Alfred Aziz (ORCID: https://orcid.org/0009-0006-1582-2113)
- Philip W. J. Burnet (ORCID: https://orcid.org/0000-0002-6374-8054)
- Daniel C. Anthony (ORCID: https://orcid.org/0000-0003-1380-6655)
- Daniel Radford‐Smith (ORCID: https://orcid.org/0000-0001-8781-7459)
- Fay Probert (ORCID: https://orcid.org/0000-0002-8580-2023)
- Erying Zhao
- Carolina Costa
Institutions
- Harbin Medical University (CN)
- Universidade do Porto (PT)
- Sainsbury Laboratory (GB)
- University of Oxford (GB)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- University College London (GB)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1177/02698811251332838
- Citations
- 1
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Biotechnology and Biological Sciences Research Council